Most runs
With 356 runs at a strike rate of 174, Fakhar Zaman is the leading run-getter of the Pakistan Super League 2021/22. Shan Masood has amassed 343 runs at a strike rate of 148, and is at second place. He was adjudged Player of the Match for his 49-ball 68 against Peshawar Zalmi. Mohammad Rizwan is next, with 249 runs at 132.
| PLAYER | MATCHES | RUNS | AVG | SR |
| Fakhar Zaman | 5 | 356 | 71.2 | 173.66 |
| Shan Masood | 6 | 343 | 57.17 | 148.48 |
| Mohammad Rizwan | 6 | 249 | 49.8 | 131.75 |
| Ahsan Ali | 5 | 211 | 52.75 | 147.55 |
| Tim David | 6 | 197 | 65.67 | 207.37 |
Most Wickets
Shadab Khan has claimed 14 wickets at 8.57, and is the leading wicket-taker of the tournament. He is followed by Khushdil Shah, who has taken 12 wickets at 8.92. Shah took three wickets against Peshawar Zalmi to help Multan Sultans win their sixth successive game.
| PLAYER | MATCHES | WKTS | AVG |
| Shadab Khan | 5 | 14 | 8.57 |
| Khushdil Shah | 6 | 12 | 8.92 |
| Imran Tahir | 6 | 11 | 14.27 |
| Shaheen Afridi | 5 | 7 | 22 |
| David Willey | 4 | 7 | 16 |