Most runs
With 248 runs at a strike rate of 187, Fakhar Zaman is the leading run-getter of the Pakistan Super League 2021/22. He is followed by Shan Masood, who has amassed 240 runs at 153. Ahsan Ali scored 50 against Islamabad United to move to third place in the list.
| PLAYER | MATCHES | INNS | RUNS | AVG | SR |
| Fakhar Zaman | 3 | 3 | 248 | 82.67 | 186.47 |
| Shan Masood | 4 | 4 | 240 | 60 | 152.87 |
| Ahsan Ali | 4 | 4 | 204 | 68 | 151.11 |
| Paul Stirling | 3 | 3 | 134 | 44.67 | 212.7 |
| Mohammad Rizwan | 4 | 4 | 133 | 44.33 | 130.39 |
Most Wickets
Khushdil Shah is the leading wicket-taker of the Pakistan Super League 2021/22, having taken nine wickets at 8.11 apiece. Imran Tahir and David Willey have claimed seven wickets each, and are followed by Shadab Khan and Shaheen Shah Afridi, who have six each. Shadab took a five-for to set up an easy win for Islamabad United.
| PLAYER | MATCHES | WKTS | AVG |
| Khushdil Shah | 4 | 9 | 8.11 |
| Imran Tahir | 4 | 7 | 15.29 |
| David Willey | 4 | 7 | 16 |
| Shadab Khan | 3 | 6 | 14.17 |
| Shaheen Afridi | 3 | 6 | 15 |